Desensitisation Treatment
Desensitisation (immunotherapy) provides long-term treatment for common allergies such as pollen, house dust mites, pets and insect stings.
At a glance
- Consultation required
- Self Referral
- Paediatric Patients Aged 0+ Seen
- Self-Pay Available
What is desensitisation?
Desensitisation, also called immunotherapy, is an effective treatment for severe allergies, including hay fever symptoms caused by aeroallergens (grass and tree pollen, house dust mites, and pets), aspirin allergy, and anaphylaxis to insect venom.
It’s currently the only option that offers a medium to long-term treatment for allergies and reduces the need for medication. In some patients, it can also improve the symptoms of allergic asthma.
In our Allergy centre, Welbeck allergists offer desensitisation to patients with a severe allergy to pollen, pets, house dust mites, aspirin, and insect venom.
Your consultant may recommend desensitisation therapy if:
you have life-threatening reactions to bee, wasp or hornet venom
you have a severe seasonal allergy to tree pollen and/or grass pollen
you have a severe perennial (all year) allergy to house dust mites or pets
you have nasal polyps and aspirin sensitivity (Samter’s triad)
you aspirin allergy and a heart condition that requires treatment with aspirin
you cannot control your symptoms with medication alone and are unable to avoid the allergen that causes your reactions
your allergy medications cause side effects or interact with other medicines you take
you want to reduce your long-term use of allergy medication
Paediatrics
We offer appointments to paediatric patients aged 0 to 18. For full information on our paediatrics service, please visit our main Paediatrics page.
More information
An allergy develops when your immune system overreacts to a substance that normally does not cause any problems, such as grass pollen or house dust mites. During immunotherapy, you’ll receive a controlled dose of the substance you’re allergic to at regular intervals to teach your immune system to tolerate it and reduce your allergy symptoms.
There are 2 main types of immunotherapy:
sublingual immunotherapy (used to treat grass pollen, tree pollen, house dust mite, and pet allergies) – you’ll be given an allergen extract under your tongue in the form of tablets or drops. The first dose of treatment is given under the supervision of an allergist, but you’ll take the following doses at home. You’ll usually take your sublingual immunotherapy treatment every day for 3 years
subcutaneous immunotherapy (aeroallergens, but mainly insect venom) – you’ll have a series of injections in your upper arm over 3 years. For safety reasons, every dose is administered by a consultant allergist, and you’ll need to stay in our Allergy centre for a short time after treatment to be monitored for signs of an allergic reaction and ensure you are safe to go home
Desensitisation is a generally safe procedure, but as with any medical procedure, there’s a small risk that complications or side effects can occur. Your consultant will explain all the possible risks and complications before your treatment and answer any questions you may have.
Potential side effects of desensitisation therapy include:
a mild rash at the injection site (with subcutaneous immunotherapy)
itching and swelling in your mouth (with sublingual immunotherapy)
sneezing, watery eyes or mild asthma symptoms
tiredness
headaches
anaphylaxis (severe allergic reaction) – this is an extremely rare, but serious complication. Symptoms include swelling of your face, tongue and throat, difficulty breathing, hives and collapse. The risk is higher (but still very low) with subcutaneous immunotherapy. If you experience anaphylaxis, our healthcare professionals at Welbeck Skin Health & Allergy are fully trained and equipped to treat it
Before you start desensitisation therapy, your consultant allergist will assess your symptoms during a consultation and perform allergy tests such as a skin prick test and/or a blood test to identify the exact allergen(s) that cause your symptoms.
Based on the results of these tests, your allergist will decide on the best treatment plan to suit your needs. Tell your consultant about any medications you take regularly and any medical conditions you have.
Before your desensitisation therapy:
you might need to stop certain drugs for 24 hours
you can eat or drink as normal before your appointment
tell your allergist if you feel unwell on the day of your appointment. They may decide to reschedule your treatment
avoid any activity that increases your heart rate, such as exercise or exposure to heat. This can increase the risk of having an allergic reaction
don’t brush your teeth immediately before taking tablets or drops
If you’re having injections (subcutaneous immunotherapy), you’ll need to stay in the department for around 30 minutes after your treatment to make sure you don’t have a severe allergic reaction. You can then go home. There’s no recovery time after desensitisation therapy, and you can resume your normal activities, including driving and returning to work or school, straight away.
Allergy symptoms won’t disappear overnight with either type of immunotherapy. However, the effect of both forms of immunotherapy can last for years after the treatment has finished, with many patients reporting less need for anti-allergy medication and an improved quality of life. How effective desensitisation therapy is varies from person to person. Some people see significant results in the early stages of treatment, while for others it can take several months or years to see an improvement.
Please contact our Allergy centre for pricing.
At Welbeck, our allergists are experts in their field and are dedicated to providing world-class care to every patient.
With access to colleagues across other specialities, our consultants are also able to refer within the Welbeck ecosystem if required to ensure you receive the treatment you need as quickly as possible, all under one roof.
All appointments, testing, treatment, and follow-up appointments take place within our state-of-the-art facilities, enabling us to deliver accurate diagnostics and advanced treatments.
We accept both self-referrals and referrals from healthcare professionals for this treatment.
If you would like to schedule a consultation with an allergist, please get in touch to make an appointment. Your health is important to us, so we strive to offer same-day appointments whenever possible.
Our consultants are recognised by the major health insurance companies. If you have private health insurance, your treatment at Welbeck can begin once you have obtained authorisation. We also provide care to self-paying patients. Learn more about the different payment options at Welbeck.
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Frequently asked questions
Desensitisation therapy may not be suitable for everyone. There are several alternative treatments for allergies, including avoiding known triggers and medications like antihistamines, decongestants and nasal corticosteroids. Talk to your consultant about alternatives to desensitisation therapy.
Yes, some forms of desensitisation therapy can be administered at home. After your initial dose is given under medical supervision, desensitisation therapy in the form of drops or tablets under your tongue (sublingual immunotherapy) can usually be continued at home. Talk to your consultant about having your desensitisation therapy at home, and any signs of adverse reaction you should be aware of.
Allergy desensitisation therapy is largely safe, and the benefits usually outweigh the risks. However, it’s important to remember that the treatment involves exposure to substances that can cause allergic reactions, which can be serious. Talk to your consultant about the risks and benefits of desensitisation therapy for your individual circumstances.
No, desensitisation therapy (immunotherapy) is not a cure for allergies. It is, however, a highly effective treatment that provides many long-term benefits, such as reducing your symptoms, decreasing your need for medication, and improving your well-being and quality of life.


